abstract：:The precise effects of HIV-1 on the gut microbiome are unclear. Initial cross-sectional studies provided contradictory associations between microbial richness and HIV serostatus and suggested shifts from Bacteroides to Prevotella predominance following HIV-1 infection, which have not been found in animal models or in ...

journal_title：EBioMedicine

authors： Noguera-Julian M,Rocafort M,Guillén Y,Rivera J,Casadellà M,Nowak P,Hildebrand F,Zeller G,Parera M,Bellido R,Rodríguez C,Carrillo J,Mothe B,Coll J,Bravo I,Estany C,Herrero C,Saz J,Sirera G,Torrela A,Navarro J,Cre

更新日期：2016-01-28 00:00:00

abstract：:Antiretroviral therapy (ART) has led to dramatic improvements in the lives of HIV-infected persons. However, residual immune activation, which persists despite ART, is associated with increased risk of non-AIDS morbidities. Accumulating evidence shows that disruption of the gut mucosal epithelium during SIV/HIV infect...

journal_title：EBioMedicine

authors： Ponte R,Mehraj V,Ghali P,Couëdel-Courteille A,Cheynier R,Routy JP

更新日期：2016-01-26 00:00:00

abstract：BACKGROUND:Following activation by vitamin K (VK), matrix Gla protein (MGP) inhibits arterial calcification, but its role in preserving renal function remains unknown. METHODS:In 1166 white Flemish (mean age, 38.2 years) and 714 South Africans (49.2% black; 40.6 years), we correlated estimated glomerular filtration (e...

journal_title：EBioMedicine

authors： Wei FF,Drummen NE,Schutte AE,Thijs L,Jacobs L,Petit T,Yang WY,Smith W,Zhang ZY,Gu YM,Kuznetsova T,Verhamme P,Allegaert K,Schutte R,Lerut E,Evenepoel P,Vermeer C,Staessen JA

更新日期：2016-01-13 00:00:00

abstract：BACKGROUND:Abnormalities in membrane excitability and Na(+) channel function are characteristic of amyotrophic lateral sclerosis (ALS). We aimed to examine the neuroprotective potential, safety and tolerability of the Na(+) channel blocker and membrane stabiliser flecainide in ALS. METHODS:A double-blind, placebo-cont...

journal_title：EBioMedicine

authors： Park SB,Vucic S,Cheah BC,Lin CS,Kirby A,Mann KP,Zoing MC,Winhammar J,Kiernan MC

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:An estimated 100,000 cases of congenital rubella syndrome (CRS) occur worldwide each year. The reported mortality rate for infants with CRS is up to 33%. The cellular mechanisms responsible for the multiple congenital defects in CRS are presently unknown. Here we identify cell types positive for rubella viru...

journal_title：EBioMedicine

authors： Lazar M,Perelygina L,Martines R,Greer P,Paddock CD,Peltecu G,Lupulescu E,Icenogle J,Zaki SR

更新日期：2015-11-27 00:00:00

abstract：BACKGROUND:Individuals of low socioeconomic status experience a disproportionate burden of chronic conditions; however it is unclear whether chronic condition burden affects survival differently across socioeconomic strata. METHODS:This retrospective cohort study used health administrative data from all residents of O...

journal_title：EBioMedicine

authors： Lane NE,Maxwell CJ,Gruneir A,Bronskill SE,Wodchis WP

更新日期：2015-11-18 00:00:00

abstract：BACKGROUND:As part of the growing lifestyle diversity in modern society, there is wide variation in the time of day individuals choose to exercise. Recent surveys in the US and Japan have reported that on weekdays, more people exercise in the evening, with fewer individuals exercising in the morning or afternoon. Exerc...

journal_title：EBioMedicine

authors： Iwayama K,Kurihara R,Nabekura Y,Kawabuchi R,Park I,Kobayashi M,Ogata H,Kayaba M,Satoh M,Tokuyama K

更新日期：2015-10-30 00:00:00

abstract：:Compelling evidence shows that fine particulate matters (PMs) from air pollution penetrate lower airways and are associated with adverse health effects even within concentrations below those recommended by the WHO. A paper reported a dose-dependent link between carbon content in alveolar macrophages (assessed only by ...

journal_title：EBioMedicine

authors： Kolosnjaj-Tabi J,Just J,Hartman KB,Laoudi Y,Boudjemaa S,Alloyeau D,Szwarc H,Wilson LJ,Moussa F

更新日期：2015-10-09 00:00:00

abstract：:Wnt/β-catenin is involved in every aspect of embryonic development and in the pathogenesis of many human diseases, and is also implicated in organ fibrosis. However, the role of β-catenin-mediated signaling on liver fibrosis remains unclear. To explore this issue, the effects of PRI-724, a selective inhibitor of the c...

journal_title：EBioMedicine

authors： Osawa Y,Oboki K,Imamura J,Kojika E,Hayashi Y,Hishima T,Saibara T,Shibasaki F,Kohara M,Kimura K

更新日期：2015-10-08 00:00:00

abstract：:Pericardial tuberculosis (TB) is associated with high therapy failure and high mortality rates. Antibiotics have to penetrate to site of infection at sufficient non-protein bound concentrations, and then enter bacteria to inhibit intracellular biochemical processes. The antibiotic concentrations achieved in pericardia...

journal_title：EBioMedicine

authors： Shenje J,Ifeoma Adimora-Nweke F,Ross IL,Ntsekhe M,Wiesner L,Deffur A,McIlleron HM,Pasipanodya J,Gumbo T,Mayosi BM

更新日期：2015-09-16 00:00:00

abstract：:Glioblastoma (GBM) is the most frequent and malignant form of primary brain tumor. GBM is essentially incurable and its resistance to therapy is attributed to a subpopulation of cells called glioma stem cells (GSCs). To meet the present shortage of relevant GBM cell (GC) lines we developed a library of annotated and v...

journal_title：EBioMedicine

authors： Xie Y,Bergström T,Jiang Y,Johansson P,Marinescu VD,Lindberg N,Segerman A,Wicher G,Niklasson M,Baskaran S,Sreedharan S,Everlien I,Kastemar M,Hermansson A,Elfineh L,Libard S,Holland EC,Hesselager G,Alafuzoff I,Westerm

更新日期：2015-08-15 00:00:00

abstract：:The last major advance in the treatment of glioblastoma multiforme (GBM) was the introduction of temozolomide in 1999. Treatment with temozolomide following surgical debulking extends survival rate compared to radiotherapy and debulking alone. However, virtually all glioblastoma patients experience disease progression...

journal_title：EBioMedicine

authors： Sharpe MA,Livingston AD,Gist TL,Ghosh P,Han J,Baskin DS

更新日期：2015-08-08 00:00:00

abstract：:Over the last decades advancements have improved survival and outcomes of severely burned patients except one population, elderly. The Lethal Dose 50 (LD50) burn size in elderly has remained the same over the past three decades, and so has morbidity and mortality, despite the increased demand for elderly burn care. Th...

journal_title：EBioMedicine

authors： Jeschke MG,Patsouris D,Stanojcic M,Abdullahi A,Rehou S,Pinto R,Chen P,Burnett M,Amini-Nik S

更新日期：2015-07-31 00:00:00

abstract：BACKGROUND:HIV sequence data can be used to reconstruct local transmission networks. Along international borders, like the San Diego-Tijuana region, understanding the dynamics of HIV transmission across reported risks, racial/ethnic groups, and geography can help direct effective prevention efforts on both sides of the...

journal_title：EBioMedicine

authors： Mehta SR,Wertheim JO,Brouwer KC,Wagner KD,Chaillon A,Strathdee S,Patterson TL,Rangel MG,Vargas M,Murrell B,Garfein R,Little SJ,Smith DM

更新日期：2015-07-18 00:00:00

abstract：BACKGROUND:Marketing authorization holders (MAHs) are obligated to report adverse events (AEs) within 15 days (some cases 30 days) to the Pharmaceuticals and Medical Devices Agency (PMDA) of Japan. METHODS:To analyze the timeliness of AE reporting to the PMDA, 6610 reports for five categories of cardiovascular devices...

journal_title：EBioMedicine

authors： Handa N,Ishii K,Matsui Y,Ando Y

更新日期：2015-07-10 00:00:00

abstract：:Disease-specific alterations of the cell-free DNA methylation status are frequently found in serum samples and are currently considered to be suitable biomarkers. Candidate markers were identified by bisulfite conversion-based genome-wide methylation screening of lung tissue from lung cancer, fibrotic ILD, and COPD. c...

journal_title：EBioMedicine

authors： Wielscher M,Vierlinger K,Kegler U,Ziesche R,Gsur A,Weinhäusel A

更新日期：2015-07-02 00:00:00

abstract：:Lung cancer is the most frequent cause of cancer-related death world-wide. Radiotherapy alone or in conjunction with chemotherapy is the standard treatment for locally advanced non-small cell lung cancer (NSCLC). Currently there is no predictive marker with clinical utility to guide treatment decisions in NSCLC patien...

journal_title：EBioMedicine

authors： Walker MJ,Zhou C,Backen A,Pernemalm M,Williamson AJ,Priest LJ,Koh P,Faivre-Finn C,Blackhall FH,Dive C,Whetton AD

更新日期：2015-06-19 00:00:00

abstract：BACKGROUND:Citizen science, scientific research conducted by non-specialists, has the potential to facilitate biomedical research using available large-scale data, however validating the results is challenging. The Cell Slider is a citizen science project that intends to share images from tumors with the general public...

journal_title：EBioMedicine

authors： Candido Dos Reis FJ,Lynn S,Ali HR,Eccles D,Hanby A,Provenzano E,Caldas C,Howat WJ,McDuffus LA,Liu B,Daley F,Coulson P,Vyas RJ,Harris LM,Owens JM,Carton AF,McQuillan JP,Paterson AM,Hirji Z,Christie SK,Holmes AR,S

更新日期：2015-05-09 00:00:00

abstract：BACKGROUND:Accelerated telomere shortening may cause cancer via chromosomal instability, making it a potentially useful biomarker. However, publications on blood telomere length (BTL) and cancer are inconsistent. We prospectively examined BTL measures over time and cancer incidence. METHODS:We included 792 Normative A...

journal_title：EBioMedicine

authors： Hou L,Joyce BT,Gao T,Liu L,Zheng Y,Penedo FJ,Liu S,Zhang W,Bergan R,Dai Q,Vokonas P,Hoxha M,Schwartz J,Baccarelli A

更新日期：2015-04-13 00:00:00

abstract：BACKGROUND:Endothelial dysfunction, characterized by diminished endothelial progenitor cell (EPC) function and flow-mediated vasodilation (FMD), is a clinically significant feature of heart failure (HF). Mesenchymal stem cells (MSCs), which have pro-angiogenic properties, have the potential to restore endothelial funct...

journal_title：EBioMedicine

authors： Premer C,Blum A,Bellio MA,Schulman IH,Hurwitz BE,Parker M,Dermarkarian CR,DiFede DL,Balkan W,Khan A,Hare JM

更新日期：2015-03-28 00:00:00

abstract：:Fibroblast growth factor receptors (FGFRs) are recognized therapeutic targets in cancer. We here describe insights underpinning the impact of mutations on FGFR1 and FGFR3 kinase activity and drug efficacy, using a combination of computational calculations and experimental approaches including cellular studies, X-ray c...

journal_title：EBioMedicine

authors： Bunney TD,Wan S,Thiyagarajan N,Sutto L,Williams SV,Ashford P,Koss H,Knowles MA,Gervasio FL,Coveney PV,Katan M

更新日期：2015-03-01 00:00:00

abstract：:Sickle cell anaemia (SCA) results from a single mutation in the β globin gene. It is seldom symptomatic in the first semester of life. We analysed the expression pattern of 9 adhesion molecules on red blood cells, in a cohort of 54 SCA and 17 non-SCA very young infants of comparable age (median 144 days, 81-196). Haem...

journal_title：EBioMedicine

authors： Brousse V,Colin Y,Pereira C,Arnaud C,Odièvre MH,Boutemy A,Guitton C,de Montalembert M,Lapouméroulie C,Picot J,Le Van Kim C,El Nemer W

更新日期：2014-12-18 00:00:00

abstract：BACKGROUND:The induction of heat shock protein (HSP) 72 by mild electrical stimulation with heat shock (MES + HS), which improves visceral adiposity and insulin resistance in mice, may be beneficial in treating metabolic syndrome (MS) or type 2 diabetes mellitus (T2DM). METHODS:Using open-label crossover trials, 40 su...

journal_title：EBioMedicine

authors： Kondo T,Ono K,Kitano S,Matsuyama R,Goto R,Suico MA,Kawasaki S,Igata M,Kawashima J,Motoshima H,Matsumura T,Kai H,Araki E

更新日期：2014-11-11 00:00:00

abstract：BACKGROUND:Sepsis involves aberrant immune responses to infection, but the exact nature of this immune dysfunction remains poorly defined. Bacterial endotoxins like lipopolysaccharide (LPS) are potent inducers of inflammation, which has been associated with the pathophysiology of sepsis, but repeated exposure can also ...

journal_title：EBioMedicine

authors： Pena OM,Hancock DG,Lyle NH,Linder A,Russell JA,Xia J,Fjell CD,Boyd JH,Hancock RE

更新日期：2014-11-01 00:00:00

abstract：:The identification of SYK as a molecular target in B-lineage leukemia/lymphoma cells prompted the development of SYK inhibitors as a new class of anti-cancer drug candidates. Here we report that induction of the SYK gene expression in human cells causes a significant down-regulation of evolutionarily conserved genes a...

journal_title：EBioMedicine

authors： Uckun FM,Ma H,Ozer Z,Goodman P,Zhang J,Qazi S

更新日期：2014-11-01 00:00:00

abstract：:Individual differences in susceptibility to human immunodeficiency virus type 1 (HIV-1) infection have been of interest for decades. We aimed to determine the contribution of large isoform of Mammalian DnaJ (MRJ-L), a HIV-1 Vpr-interacting cellular protein, to this natural variation. Expression of MRJ-L in monocyte-de...

journal_title：EBioMedicine

authors： Chiang YP,Sheng WH,Shao PL,Chi YH,Chen YM,Huang SW,Shih HM,Chang LY,Lu CY,Chang SC,Hung CC,Huang LM

更新日期：2014-10-07 00:00:00